Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome

Authors: Boutin, Thibaud; Bretherick, Andrew D.; Dibble, Joshua J.; Ewaoluwagbemiga, Esther; Northwood, Emma; Samms, Gemma L.; Vitart, Veronique; Almelid, Øyvind; Baker, Tom; Clyde, Malgorzata; Connolly, Anne; Garcia, Diana; Kerr, Shona M.; Tripp, Claire; Wolfe, Jareth C.; Goold, Jackie; Hoyes, Gemma; Leary, Sian; McGrath, Simon J.; Milton, Julie; Redshaw, Anna; Wilson, Jim M.; Baxter, Helen; Boobyer, Danielle; Dransfield, Claire; Lamirel, Daphne; Lewis, Isabel; Muirhead, Nina; Ponting, Ella; Shepherd, Charles; Turner, Alice; Baby, Sumy V.; Beentjes, Sjoerd; Ireland, John; Khamseh, Ava; McDowall, Ewan; Perry, David; Slaughter, Joshua; Abner, Erik; Boer, Cindy G.; Finer, Sarah; Haapaniemi, Hele; Ollila, Hanna M.; Pollack, Beth; Rosmalen, Judith; Romppanen, Erika; Saafi, Sirine; Saxena, Richa; Sinnott-Armstrong, Nasa; Tervi, Anniina; Urpa, Lea; Valliere, Jesse; van Heel, David A.; Chowdhury, Sonya; Devereux-Cooke, Andy; Ponting, Chris P.

8 Aug 2025 (Preprint)

View article | Discussion on S4ME


Cohorts in this study

Phenotype: ME/CFS, Post-exertional malaise (PEM)

ABT1, ANKRD45, ARFGEF2, B4GALT5, BTN2A2, BTN3A3, CA10, CACNA1E, CCDC92, CCPG1, CDK5RAP1, CSE1L, DARS2, DCC, DDX27, DNAH10, DNAJC1, ECI2, FBXL4, GPR52, H4C8, HFE, HMGN4, HTT, KLHL20, LRRC7, LRRIQ3, MLLT10, MMS22L, MRPL39, NEGR1, OLFM4, PCDH17, PEBP1, PLCL1, POU3F2, PRDX6, PTGIS, RABGAP1L, RC3H1, SERPINC1, SHISA6, SLC2A14, SLC9C2, SOX6, STAU1, SUDS3, TAOK3, TNFSF4, TRIM38, UNC13C, VRK2, VSIG10, ZBTB37, ZNF311, ZNF322, ZNF644, ZNF664, ZNFX1

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Notes

Tier 1 and 2 genes, MAGMA genes, and genes nearest to top 8 loci.