Precision Medicine Study of Post-Exertional Malaise Epigenetic Changes in Myalgic Encephalomyelitis/Chronic Fatigue Patients During Exercise

Authors: Sharma, Sayan; Hodges, Lynette D.; Peppercorn, Katie; Davis, Jemma; Edgar, Christina D.; Rodger, Euan J.; Chatterjee, Aniruddha; Tate, Warren P.

International Journal of Molecular Sciences, 3 Sep 2025

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Cohorts in this study

Phenotype: ME/CFS, Post-exertional malaise (PEM)

ACR, AMER1, APCDD1L, APEX2, C7, CEBPB, CHST7, DPM2, ERF, FAM3A, FFAR2, INTS6L, MSR1, NPBWR2, OR2V1, PRRG3, RBBP8NL, RNPS1, TMEM187, ZAP70, ZDHHC9, ZG16B, ZNF135, ZNF785

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Notes

Genes from table 2: "Among the 205 unique ME/CFS DMFs across the three timepoints of CPET, there were 24 gene promoter fragments in each of the five ME/CFS patients that could be linked to specific genes (Table 2)."