Identification of Novel Reproducible Combinatorial Genetic Risk Factors for Myalgic Encephalomyelitis in the DecodeME Patient Cohort and Commonalities with Long COVID

Authors: Sardell, JM; Das, S; Pearson, M; Kolobkov, D; Malinowski, AR; Fullwood, LM; Sanna, M; Baxter, H; McLellan, K; Natt, M; Lamirel, D; Chowdhury, S; Strivens, MA; Gardner, S

2 Dec 2025 (Preprint)

View article | Discussion on S4ME


Cohorts in this study

Phenotype: ME/CFS

AAMDC, ABCA1, ABCC6, ABHD12, ACOX3, ACTL8, ACTR3C, ADAMTS2, ADPRH, ADTRP, AFF1, AFF3, AKAP2, AKAP6, ALDOB, ANGPT1, ANKS1B, ANO3, ANO4, ARB2A, ARHGAP8, ASB2, ASB3, ASXL3, ATCAY, ATXN1, BAG6, BCCIP, BNC2, BRF1, BTBD2, BTBD7, BTBD9, C18orf63, C1orf87, C20orf173, C3, C5orf47, CACNA1A, CACNA1D, CBFA2T3, CCDC148, CCDC149, CCDC171, CCDC85A, CD22, CD82, CD8B, CDH12, CDH13, CELF2, CEP19, CH25H, CHCHD6, CHL1, CKAP4, CNTN4, COL19A1, COL4A4, COLEC12, COX17, CRYBG2, CSE1L, CSMD1, CTNNA2, CYB5RL, CYFIP1, CYP7B1, DAB1, DCC, DDAH1, DDR1, DENND2A, DHX32, DISP2, DLGAP2, DMAC1, DNAH11, DNAJA4, DNAJC25, DOCK2, DPP3, DPP6, EEPD1, EFCAB5, EHMT1, EPHB1, F13A1, FARP1, FBXO7, FHIT, FNTB, FOCAD, FRAS1, FREM3, FRMD4A, FTO, FUT8, GABBR1, GABRB1, GALNT18, GCNT1, GINS1, GNL3, GPSM2, GRIA1, GRIK1, GRK4, GRM7, H2BC6, H2BC7, HACD1, HS3ST4, IGF1R, IGF2BP3, INPP4B, KANSL1, KAZN, KCNIP4, KCNJ16, KLHDC4, KSR1, LAIR1, LOXL2, LPA, LPP, LRMDA, LRRC74A, LYPD5, MAML2, MAX, MDGA2, MED13L, MED25, MICB, MMAB, MOV10, MRPL37, MSI2, MTX2, MUC16, MYT1L, NBEAL2, NCKAP5, NCOR2, NDST3, NECTIN1, NEDD9, NFIA, NOP9, NOS1AP, NTN1, NTRK3, OR10A6, OR5AC2, OR5V1, PARD3B, PARM1, PARS2, PAX5, PCSK6, PDE1C, PDIA3, PEBP4, PIGX, PKM, PLCB1, PLD5, POPDC2, PPM1N, PPP1R36, PSMB9, PTPRD, PTPRG, PUS10, RAI14, RAP1GAP2, RASGEF1B, RASGRF2, RB1CC1, RBFOX1, RERE, RERGL, RGS7, RHBDD2, RHBDL3, RNF150, RYR2, RYR3, SAMD5, SASH1, SCAMP3, SEC23IP, SEZ6L, SFMBT2, SFTA2, SGSM2, SH3PXD2A, SH3RF3, SLC17A2, SLC25A24, SLC28A1, SLC35F3, SLC39A12, SLC5A10, SLCO2A1, SMARCA2, SNX29, SPMIP2, SPOCK1, SPOCK3, SPTLC3, SRGAP1, ST6GAL1, STAB1, STIM2, STOX2, SUB1, SULT1C3, SYTL3, TACC1, TAP1, TENM2, THSD7A, TLR3, TM7SF3, TMEM132C, TMEM260, TMEM63C, TMTC1, TOX3, TPH2, TPX2, TRIM26, TRIM31, TSKU, TTC39C, TTLL11, TUBB, UGGT1, UNC93A, UROS, USP45, USP47, UTRN, VIT, XYLT1, YWHAB, ZC3H3, ZC3H7A, ZIC4, ZMAT4, ZNF282, ZNF283, ZNF385B, ZNF423, ZPLD1, ZSCAN5C, ZZEF1

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Notes

Data from "Extended Table 3. Table listing 259 candidate core genes identiied in this study."