Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in long COVID patients with ME/CFS

Authors: Shahbaz, Shima; Osman, Mohammed; Syed, Hussain; Mason, Andrew; Rosychuk, Rhonda J.; Cohen Tervaert, Jan Willem; Elahi, Shokrollah

Cell Reports Medicine, Nov 2025

View article | Discussion on S4ME


Cohorts in this study

Phenotype: Long COVID, ME/CFS, ME/CFS - Canadian Consensus Criteria (CCC), Post-exertional malaise (PEM)

ACHE, AHCTF1P1, AR, ARTN, BRINP2, CASP5, CCL2, CCL22, CCL26, CCL3, CD101, CD14, CD164, CD200R1, CD226, CD302, CD320, CD36, CD3E, CD48, CD6, CD68, CD69, CD7, CD79A, CD81, CD82, CFD, CHPF, CLEC4D, CRP, CXCL10, CXCL8, CXCR3, DGKK, DNAAF2, DSC2, EEF1A1P11, EGR3, ENG, EPSTI1, ESR1, ESR2, ESRRG, FABP2, FAM161B, FAM83A, FCGBP, FCGR1BP, FEZF2, FLT1, FMC1-LUC7L2, FOXO4, FOXP3, GMPR, GNG10, GUSBP15, GUSBP5, GYPA, GZMA, HBG2, HLA-DRB5, HOXC12, ICAM1, IFNA20P, IFNG, IFNGR1, IGF2, IGHA2, IGHGP, IL10, IL11RA, IL12RB1, IL15RA, IL16, IL17A, IL1A, IL27, IL27RA, IL2RA, IL2RB, IL32, IL33, IL6, IL9RP3, ITPRIPL2, JPH3, KCNQ5, KIR3DL2, LBP, LGALS9, LYZ, MCC, MEIS1, MEIS2, MTND4P14, MTND4P26, MTND5P28, MUC12, NECTIN2, NR3C1, NRXN2, ORC4, PAFAH1B1, PALB2, PGF, PLA2G10IP, POM121B, PTGES3P1, PTMAP12, RAB1AP1, RELN, RNA5-8SP6, RNA5SP226, RNA5SP389, ROCK1P1, RPL17-C18orf32, RPL29, RPL39, RPL6P27, RPS3A, SAA1, SAPCD2P3, SCAF8, SCARF2, SEPTIN14P2, SKOR2, SLC7A8, SMAD6, SYCE1, SYCE1L, TFRC, TGFB1, TGFBR1, TNF, TRIM74, TSNAX-DISC1, TUBB6, UTF1, VCAM1, VEGFB, VEGFC, WDR62, ZACN, ZCCHC14, ZFHX3, ZNF469

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Notes

Data from throughout text of Results section and Fig 6I and 6J